Oder kann diese temporäre Braunfärbung auch auftreten bei einer Fehlfunktion der übergeordneten Regulation im Gehirn, der Hypophyse oder des Hypothalamus, also der sekundären Nebennierenrindeninsuffizienz?
Normalerweise liest man immer, tritt nur bei der primären Form auf, aber kennt jemand Ausnahmen?
Kann so eine sekundäre Nebenniereninsuffiiziens auch als Nebenwirkung von langjähriger Morphineinnahme auftreten? Morphine haben ja auch einen Einfluß auf die Hormone, es kann die Menstruation ausbleiben.
Habe hierzu folgendes gefunden:
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Opiate and endocrine interaction: morphine effects on hypothalamus and pineal body. Dafny N, Burks TF. Abstract Experiments were performed on male Holtzman albino rats. Stainless steel semimicroelectrodes 60 micron in diameter were implanted stereotaxically in the ventromedial hypothalamus (VMH) and in the pineal body (PB). Six to eight days following this operation, the sensory field potentials from freely behaving, unrestrained rats were averaged. After a control recording was achieved, animals were given injections i.p. with 10,30 or 50 mg/kg of morphine and recordings were resumed for 45 min. Naloxone was then administered and recordings were monitored during another 45 min period. Three consistent components of the averaged sensory evoked potentials were evaluated. In both structures following the two lower doses of morphine (10 and 30 mg/kg), increased and decreased response amplitudes were observed, while following 50 mg/kg morphine, mainly increased response amplitudes were obtained in both structures. With increased doses, the percentage of responses was increased. During the 45 min of recording after morphine, effects remained consistent. Differences in the percentage and the direction of the responses were observed between the VMH and the PB. Naloxone (1 mg/kg) reversed the morphine effect in the two structures, both the increased and decreased responses. The possible interactions between morphine and endocrine function of the two structures are discussed.
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ffects of morphine on hypothalamic corticotropin-releasing factor (CRF), norepinephrine and dopamine in non-stressed and stressed rats. Suemaru S, Hashimoto K, Ota Z. Abstract The effects of morphine on the hypothalamic corticotropin-releasing factor (CRF), norepinephrine (NE) and dopamine (DA) concentrations were investigated in non-stressed and stressed rats. Acutely administered morphine stimulated both the synthesis and release of CRF in the hypothalamus, thereby activating the pituitary-adrenocortical system in non-stressed rats, but inhibited the stress-induced CRF synthesis and ACTH-corticosterone secretion. Either a morphine or ether-laparotomy stress reduced NE and DA concentrations in the hypothalamus. A pretreatment with morphine inhibited the stress-induced reduction in the hypothalamic NE and DA concentrations, and induced a significant increase in the DA concentration. These observations suggest that hypothalamic NE and DA are involved in morphine-induced changes in hypothalamo-pituitary-adrenocortical (HPA) activity and that endogenous opiates have a role in regulating CRF secretion by interacting with hypothalamic biogenic amines.
Reicht ein normales Blutbild mit Nierenwerten aus, um die Erkrankung zu bestimmen? Oder zumindestens für die Feststellung eines Anfangsverdachts?
Danke im Voraus!